100-401-A04
Cul4A Antibody
Cannot supply to this region.
- SKU:
- 100-401-A04
- Additional Names:
- CUL4A|rabbit anti-Cul4A Antibody, 2810470J21Rik antibody, AW495282 antibody, CUL 4A antibody, CUL4A antibody, Cul4a protein antibody, MGC36573 antibody, MGC64071 antibody, CUL, Cullin
- Application:
- ELISA, IHC, WB, IP
- Concentration:
- 85 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human
- Immunogen:
- This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the N-Terminal region near amino acids 1-25 of Human Cul4A coupled to KLH.
- Format:
- Antiserum
- Uniprot:
- Q13619
- Synonyms:
- CUL-4A;cullin-4A
- Extra Details:
- Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. Cullin 4a is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, cul4A serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. Cul4A may also contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Cul4A also interacts with RNF7 and is part of a complex with TIP120A/CAND1, Cyclin E and RBX1.
- Shipping Conditions:
- Dry Ice