100-401-244
Smac/Diablo Antibody
Cannot supply to this region.
- SKU:
- 100-401-244
- Additional Names:
- DIABLO|rabbit anti-smac antibody, rabbit anti-Diablo antibody, Diablo homolog mitochondrial, Second mitochondria-derived activator of caspase, Smac protein
- Application:
- ELISA, WB, IP
- Concentration:
- 85 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- This whole rabbit serum was prepared by repeated immunizations with recombinant His6-tagged human Smac/DIABLO protein (amino acids 56-239).
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Format:
- Antiserum
- Uniprot:
- Q9NR28, Q9NR28.1
- Synonyms:
- DFNA64;diablo homolog, mitochondrial;diablo-like protein;direct IAP-binding protein with low pI;second mitochondria-derived activator of caspase;SMAC
- Extra Details:
- Apoptosis is a conserved cell suicide program essential for the development and homeostasis of multi-cellular organisms. Abnormal inhibition of apoptosis is a hallmark of cancer and autoimmune diseases, whereas excessive cell death is found in neurodegenerative disorders such as Alzheimers disease. Executioners of the apoptotic program are cysteine proteases termed caspases that exist as inactive zymogens in living cells and are activated during apoptosis. Active caspases cleave key intracellular protein substrates, resulting in the characteristic morphological changes associated with apoptosis. The release of cytochrome c from the mitochondria triggers the oligomerization of Apaf-1 in an ATP/dATP-dependent manner and induces the autoactivation of caspase-9. Active caspase-9 in turn activates downstream effector caspases including caspase -3, -6 and -7.
- Shipping Conditions:
- Dry Ice