100-401-220P
IKK beta Peptide
Cannot supply to this region.
- SKU:
- 100-401-220P
- Additional Names:
- IKKB, I-kappa-B-kinase beta, IKK-B antibody, IKK-beta, IkBKB, I-kappa-B kinase 2, Nuclear factor NF-kappa-B inhibitor kinase beta, NFKBIKB, IKK2, control peptide, blocking peptide
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Purity:
- >95%
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Species:
- Human
- Uniprot:
- O14920
- Synonyms:
- I-kappa-B kinase 2;I-kappa-B-kinase beta;IKK-beta;IKK2;IKKB;IMD15;IMD15A;IMD15B;inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta;inhibitor of nuclear factor kappa-B kinase subunit beta;NFKBIKB;nuclear factor NF-kappa-B inhibitor kinase beta;serine/threonine protein kinase IKBKB
- Extra Details:
- Intended for use as a control peptide when used with anti-IKKB to block specific interaction of anti-IKKB [p/n 100-401-220]. NFkB comprises a family of cellular transcription factors that are involved in the inducible expression of a variety of cellular genes that regulate the inflammatory response and control of cell death. In the cytoplasm NFkB is negatively modulated by the inhibitory proteins IkB. In turn IkB is phosphorylated by a cellular kinase complex called IKK. IKK is a heterodimer composed of two kinases: IKK-a and IKK-b that phosphorylate IkB leading to its degradation and the resulting translocation of NFkB to the nucleus. IKK kinase activity is modulated negatively by pharmaceutical agents such as aspirin and positively by various cellular components such as TNF- a, endotoxins and overexpression of cellular kinases like MEKK1. Aspirin appears to have its effect by inhibiting the binding of ATP to IKK.
- Shipping Conditions:
- Dry Ice