100-401-199
Thymidylate Synthase Antibody
Cannot supply to this region.
- SKU:
- 100-401-199
- Additional Names:
- rabbit anti-Thymidylate Synthase Antibody, d TMP synthase antibody, HsT422 antibody, MGC88736 antibody|TYMS
- Application:
- ELISA, IHC, WB
- Concentration:
- 85 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human
- Immunogen:
- This whole rabbit serum was prepared by repeated immunizations with recombinant human Thymidylate Synthase (36 kDa) produced in E.coli.
- Format:
- Antiserum
- Uniprot:
- P04818, P04818.3
- Synonyms:
- HST422;thymidylate synthase;TMS;TS;TSase
- Extra Details:
- Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript rTS alpha vary inversely when cell-growth progresses from late-log to plateau phase. Diseases associated with Thymidylate synthase include Rectal Neoplasm and Dihydropyrimidine Dehydrogenase Deficiency. Anti-Thymidylate synthase is useful for researchers interested in Circadian Rhythm, Metabolism and cell cycle research.
- Shipping Conditions:
- Dry Ice