100-101-092
Uricase Antibody
Cannot supply to this region.
- SKU:
- 100-101-092
- Additional Names:
- ABC3735|Uricase, ABC3735, goat anti-Uricase Antibody, goat anti-Uricase bacillus Antibody, urate oxidase (UO), factor-independent urate hydroxylase
- Application:
- ELISA, WB, IP
- Concentration:
- 90 mg/ml
- Physical State:
- Lyophilized
- Species Reactivity:
- Bacteria
- Storage Conditions:
- 2-8[o]C liquid. Aliquot. Avoid freeze/thaw cycles., -20[o]C/-70[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Goat
- Reactivities:
- Bacteria
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- Uricase [Bacillus species]
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Format:
- Antiserum
- Uniprot:
- Q5WBJ3
- Synonyms:
- ABC3735;Urate oxidase
- Extra Details:
- Uricase, or urate oxidase, catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Urate oxidase is found in nearly all organisms, from bacteria to mammals, and plays different metabolic roles, depending on its host organism. Humans are the only animal that are unable to break down uric acid to allantoin. This is because humans do not have the necessary enzyme uricase. Humans do have a gene for urate oxidase, but it is nonfunctional. Thus uric acid is the end product of animal products in humans. This leads to an increased possibility of an accumulation of uric acid in the body when animal products are eaten. Excessive concentration of uric acid in the blood stream leads to gout. It has been proposed that the loss of urate oxidase gene expression has been advantageous to primates, since uric acid is a powerful antioxidant and scavenger of singlet oxygen and radicals. Its presence provides the body with protection from oxidative damage, thus prolonging life and decreasing age-specific cancer rates.
- Shipping Conditions:
- Ambient