000-001-C19
Crasp2 Control Protein
Cannot supply to this region.
- SKU:
- 000-001-C19
- Additional Names:
- control protein, Borrelia burgdorferi CRASP-2, CRASP2|cspZ, BB_H06
- Application:
- ELISA, SDS-PAGE, WB, Functional Assay
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Purity:
- >90%
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Rockland Inc
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- cspZ, BB_H06
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Species:
- Bacteria
- Uniprot:
- O50665
- Synonyms:
- BB_H06;BB_RS04320;factor H-binding protein CspZ
- Extra Details:
- CRASP-2 (Complement Regulator-Acquiring Surface Protein 2) of Borrelia burgdorferi binds FHL-1 and factor H binding protein in a distinct way. It may be predominantly expressed by serum-resistant Borrelia strains. Borrelia burgdorferi sensu lato has the ability to evade immune systems to persist in a variety of vertebrate hosts. This activity is dependent on a number of factors. Some Borrelia species bind host-derived fluid-phase immune regulators FHL-1 and factor H to their surface via complement regulator-acquiring surface proteins (CRASPs). Factor H and FHL-1 serve as cofactors for factor I, a serine protease that cleaves complement component 3b (C3b) directly on the cell surface and thereby confers resistance of spirochetes to complement-mediated lysis. It is possible that because of discontinuous binding regions in the factor H/FHL-1, long distance interaction may be involved in binding of both immune regulators. Putative coiled-coil structural elements may be important in the interaction of B. burgdorferi CRASP-1 with factor H. Lyme disease proteins are ideal for researchers interested in immunology, neurology, rheumatology, coinfections, autoimmune, and neurodegenerative diseases.
- Shipping Conditions:
- Dry Ice