GTX89949-PEP
BLNK blocking peptide
Cannot supply to this region.
- SKU:
- GTX89949-PEP
- Additional Names:
- B Cell Linker , Agm4 , Bash , Blnk-S , Ly57 , Slp-65 , Slp65 , Bca , Blnk
- Physical State:
- Lyophilized
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Buffer:
- Reconstitute with 200ul distilled water to obtain a 0.5mg/ml peptide solution. Lyophilized from 5% (v/v) acetonitrile/H₂O, no preservatives.
- Immunogen:
- B-cell linker
- Species:
- Human
- Synonyms:
- AGM4;B cell adaptor containing SH2 domain;B-cell activation;B-cell adapter containing a SH2 domain protein;B-cell adapter containing a Src homology 2 domain protein;B-cell linker protein;BASH;bca;BLNK-S;cytoplasmic adapter protein;LY57;SLP-65;SLP65;Src homology [SH2] domain-containing leukocyte protein of 65 kD;Src homology 2 domain-containing leukocyte protein of 65 kDa
- Extra Details:
- This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
- Shipping Conditions:
- Blue Ice