GTX89837-PEP
ALS2 blocking peptide
Cannot supply to this region.
- SKU:
- GTX89837-PEP
- Additional Names:
- Als2, Alsin Rho Guanine Nucleotide Exchange Factor , Als2Cr6 , Alsj , Iahsp , Plsj , Als2
- Physical State:
- Lyophilized
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Buffer:
- Reconstitute with 200ul distilled water to obtain a 0.5mg/ml peptide solution. Lyophilized from 5% (v/v) acetonitrile/H₂O, no preservatives.
- Immunogen:
- ALS2, alsin Rho guanine nucleotide exchange factor
- Species:
- Human
- Synonyms:
- ALS2, alsin Rho guanine nucleotide exchange factor;ALS2CR6;alsin;ALSJ;amyotrophic lateral sclerosis 2 (juvenile);amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein;amyotrophic lateral sclerosis 2 protein;IAHSP;PLSJ
- Extra Details:
- The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
- Shipping Conditions:
- Blue Ice