GTX89707-PEP
WHIP blocking peptide
Cannot supply to this region.
- SKU:
- GTX89707-PEP
- Additional Names:
- Werner Helicase Interacting Protein 1 , Whip , Ba420G6.2 , Wrnip1
- Physical State:
- Lyophilized
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Buffer:
- Reconstitute with 200ul distilled water to obtain a 0.5mg/ml peptide solution. Lyophilized from 5% (v/v) acetonitrile/H₂O, no preservatives.
- Immunogen:
- Werner helicase interacting protein 1
- Species:
- Human
- Synonyms:
- ATPase WRNIP1;bA420G6.2;CFAP93;FAP93;putative helicase RUVBL;Werner helicase interacting protein 1;WHIP
- Extra Details:
- Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]
- Shipping Conditions:
- Blue Ice