GTX89576-PEP
PDHX blocking peptide
Cannot supply to this region.
- SKU:
- GTX89576-PEP
- Additional Names:
- Pyruvate Dehydrogenase Complex Component X , Dldbp , E3Bp , Opdx , Pdhxd , Pdx1 , Prox , Pdhx
- Physical State:
- Lyophilized
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Buffer:
- Reconstitute with 200ul distilled water to obtain a 0.5mg/ml peptide solution. Lyophilized from 5% (v/v) acetonitrile/H₂O, no preservatives.
- Immunogen:
- pyruvate dehydrogenase complex component X
- Species:
- Human
- Synonyms:
- dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex;DLDBP;E3BP;lipoyl-containing pyruvate dehydrogenase complex component X;OPDX;PDHXD;PDX1;proX;pyruvate dehydrogenase complex, E3-binding protein subunit;pyruvate dehydrogenase complex, lipoyl-containing component X;pyruvate dehydrogenase protein X component, mitochondrial
- Extra Details:
- The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile
- Shipping Conditions:
- Blue Ice