SH2D1A blocking peptide

Cannot supply to this region.

SKU:: GTX89516-PEP
Additional Names:: Sh2 Domain Containing 1A , Dshp , Ebvs , Imd5 , Lyp , Mtcp1 , Sap , Sap/Sh2D1A , Xlp , Xlpd , Xlpd1 , Sh2D1A
Physical State:: Lyophilized
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Buffer:: Reconstitute with 200ul distilled water to obtain a 0.5mg/ml peptide solution. Lyophilized from 5% (v/v) acetonitrile/H₂O, no preservatives.
Immunogen:: SH2 domain containing 1A
Species:: Human
Synonyms:: DSHP;Duncan disease SH2-protein;EBVS;IMD5;LYP;MTCP1;SAP;SAP/SH2D1A;SH2 domain-containing protein 1A;signaling lymphocyte activation molecule-associated protein;signaling lymphocytic activation molecule-associated protein;SLAM associated protein/SH2 domain protein 1A;SLAM-associated protein;T cell signal transduction molecule SAP;XLP;XLPD;XLPD1
Extra Details:: This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Shipping Conditions:: Blue Ice