GTX89245-PEP
CCM2 blocking peptide
Cannot supply to this region.
- SKU:
- GTX89245-PEP
- Additional Names:
- Ccm2 Scaffold Protein , C7Orf22 , Osm , Pp10187 , Ccm2
- Physical State:
- Lyophilized
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Buffer:
- Reconstitute with 200ul distilled water to obtain a 0.5mg/ml peptide solution. Lyophilized from 5% (v/v) acetonitrile/H₂O, no preservatives.
- Immunogen:
- CCM2 scaffolding protein
- Species:
- Human
- Synonyms:
- C7orf22;CCM2 scaffolding protein;cerebral cavernous malformation 2;cerebral cavernous malformations 2 protein;malcavernin;OSM;osmosensing scaffold for MEKK3;PP10187
- Extra Details:
- This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
- Shipping Conditions:
- Blue Ice