GTX89030-PEP
NCF4 blocking peptide
Cannot supply to this region.
- SKU:
- GTX89030-PEP
- Additional Names:
- Neutrophil Cytosolic Factor 4 , Cgd3 , Ncf , P40Phox , Sh3Pxd4 , Ncf4
- Physical State:
- Lyophilized
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Buffer:
- Reconstitute with 200ul distilled water to obtain a 0.5mg/ml peptide solution. Lyophilized from 5% (v/v) acetonitrile/H₂O, no preservatives.
- Immunogen:
- neutrophil cytosolic factor 4
- Species:
- Human
- Synonyms:
- CGD3;NCF;NCF-4;neutrophil cytosol factor 4;neutrophil cytosolic factor 4, 40kDa;neutrophil NADPH oxidase factor 4;p40-phox;P40PHOX;SH3 and PX domain-containing protein 4;SH3PXD4
- Extra Details:
- The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
- Shipping Conditions:
- Blue Ice