GTX89025-PEP
APH1A blocking peptide
Cannot supply to this region.
- SKU:
- GTX89025-PEP
- Additional Names:
- Aph-1 Homolog A, Gamma-Secretase Subunit , 6530402N02Rik , Aph-1 , Aph-1A , Cgi-78 , Aph1A
- Physical State:
- Lyophilized
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Buffer:
- Reconstitute with 200ul distilled water to obtain a 0.5mg/ml peptide solution. Lyophilized from 5% (v/v) acetonitrile/H₂O, no preservatives.
- Immunogen:
- aph-1 homolog A, gamma secretase subunit
- Species:
- Human
- Synonyms:
- 6530402N02Rik;anterior pharynx defective 1 homolog A;APH-1;APH-1A;aph-1alpha;APH1A gamma secretase subunit;CGI-78;gamma-secretase subunit APH-1A;presenilin-stabilization factor
- Extra Details:
- This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011]
- Shipping Conditions:
- Blue Ice