GTX88471
EWSR1 antibody, Internal
Cannot supply to this region.
- SKU:
- GTX88471
- Additional Names:
- EWS RNA binding protein 1 , EWS , EWS-FLI1 , bK984G1.4
- Application:
- WB, IHC-P
- Concentration:
- 0.50 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Ammonium Sulfate Precipitated; Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Goat
- Reactivities:
- Human
- Buffer:
- TBS, 0.5% BSA, 0.02% Sodium azide.
- Immunogen:
- Peptide with sequence C-TSYDQSSYSQQNTYG, from the internal region of the protein sequence according to NP_053733.2; NP_005234.1; NP_001156757.1; NP_001156758.1; NP_001156759.1.
- Uniprot:
- Q01844
- Synonyms:
- bK984G1.4;Ewing sarcoma breakpoint region 1;Ewing sarcoma breakpoint region 1 protein;Ewings sarcoma EWS-Fli1 (type 1) oncogene;EWS;EWS oncogene;EWS RNA-binding protein variant 6;EWS-FLI1;RNA-binding protein EWS
- Extra Details:
- This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]
- Shipping Conditions:
- Blue Ice