GTX88456
HMGCR antibody, Internal
Cannot supply to this region.
- SKU:
- GTX88456
- Additional Names:
- 3-hydroxy-3-methylglutaryl-CoA reductase , LDLCQ3
- Application:
- WB
- Concentration:
- 0.50 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Ammonium Sulfate Precipitated; Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Goat
- Reactivities:
- Human, Mouse
- Buffer:
- TBS, 0.5% BSA, 0.02% Sodium azide.
- Immunogen:
- Peptide with sequence C-ADPSPQNSTADTSK , from the internal region of the protein sequence according to NP_000850.1.
- Uniprot:
- P04035
- Synonyms:
- 3-hydroxy-3-methylglutaryl CoA reductase (NADPH);3-hydroxy-3-methylglutaryl-Coenzyme A reductase;HMG-CoA reductase;hydroxymethylglutaryl-CoA reductase;LDLCQ3
- Extra Details:
- HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
- Shipping Conditions:
- Blue Ice