GTX88214
UNC45B antibody, Internal
Cannot supply to this region.
- SKU:
- GTX88214
- Additional Names:
- unc-45 myosin chaperone B , CMYA4 , CTRCT43 , SMUNC45 , UNC-45B , UNC45
- Application:
- WB, IF, ICC
- Concentration:
- 0.50 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Ammonium Sulfate Precipitated; Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Goat
- Reactivities:
- Human
- Buffer:
- TBS, 0.5% BSA, 0.02% Sodium azide.
- Immunogen:
- Peptide with sequence C-RSDKLRQKIFKER, from the internal region of the protein sequence according to NP_775259.1; NP_001028748.1.
- Uniprot:
- Q8IWX7
- Synonyms:
- cardiomyopathy associated 4;CMYA4;CTRCT43;MFM11;protein unc-45 homolog B;SMUNC45;striated muscle UNC45;unc-45 homolog B;UNC-45B;UNC45
- Extra Details:
- This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
- Shipping Conditions:
- Blue Ice