GTX88068
NALP2 antibody, C-term
Cannot supply to this region.
- SKU:
- GTX88068
- Additional Names:
- NLR family pyrin domain containing 2 , CLR19.9 , NALP2 , NBS1 , PAN1 , PYPAF2
- Application:
- WB
- Concentration:
- 0.50 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Ammonium Sulfate Precipitated; Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Goat
- Reactivities:
- Human
- Buffer:
- TBS, 0.5% BSA, 0.02% Sodium azide.
- Immunogen:
- Peptide with sequence C-KNPQLIIDTEKHHP, from the C Terminus (near) of the protein sequence according to NP_060322.1.
- Uniprot:
- Q9NX02
- Synonyms:
- CLR19.9;NACHT, leucine rich repeat and PYD containing 2;NACHT, LRR and PYD domains-containing protein 2;NALP2;NBS1;nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2;nucleotide-binding site protein 1;PAN1;PYPAF2;PYRIN domain and NACHT domain-containing protein 1;PYRIN-containing APAF1-like protein 2
- Extra Details:
- This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
- Shipping Conditions:
- Blue Ice