GTX87684
HIRA antibody
Cannot supply to this region.
- SKU:
- GTX87684
- Additional Names:
- DGCR1 , HIRA , TUP1 , TUPLE1 , histone cell cycle regulator
- Application:
- IHC-P
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 150mM NaCl, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human HIRA (521-570).
- Uniprot:
- P54198
- Synonyms:
- DGCR1;DiGeorge critical region gene 1;HIR histone cell cycle regulation defective homolog A;histone regulator A;protein HIRA;TUP1;TUP1-like enhancer of split protein 1;TUPLE1
- Extra Details:
- This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]
- Shipping Conditions:
- Blue Ice