ARMER antibody

Cannot supply to this region.

SKU:: GTX85516
Additional Names:: ADP ribosylation factor like GTPase 6 interacting protein 1 , AIP1 , ARL6IP , ARMER , SPG61
Application:: ELISA, WB, IHC-P, IHC-Fr
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Ion Exchange
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: PBS, 0.02% Sodium azide.
Immunogen:: ARMER antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human ARMER.The immunogen is located within the last 50 amino acids of ARMER.
Uniprot:: Q15041
Synonyms:: ADP-ribosylation factor GTPase 6 interacting protein 1;ADP-ribosylation factor-like 6 interacting protein 1;ADP-ribosylation factor-like protein 6-interacting protein 1;aip-1;AIP1;apoptotic regulator in the membrane of the endoplasmic reticulum;ARL-6-interacting protein 1;ARL6IP;ARMER;SPG61
Extra Details:: Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA (1). Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12 (2), other caspases such as caspase-9 are also thought to be activated following ER stress (3). Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity (3), although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.

Shipping Conditions:: Blue Ice