GTX85453
GAD67 antibody
Cannot supply to this region.
- SKU:
- GTX85453
- Additional Names:
- glutamate decarboxylase 1 , CPSQ1 , GAD , SCP
- Application:
- IHC, WB, IHC-P, IF, ICC
- Concentration:
- 100 ug/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Genetex
- Host:
- Chicken/Avian
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- Chickens were immunized with a synthetic peptide / keyhole limpet hemocyanin (KLH) conjugate. This synthetic peptide corresponded to a region near the C-terminus of this gene product, and was 100% conserved between the human (Q99259, NCBI), mouse (P48318, NCBI) and rat (NP_058703, NCBI) gene products.
- Uniprot:
- Q99259
- Synonyms:
- 67 kDa glutamic acid decarboxylase;CPSQ1;DEE89;GAD;GAD-67;glutamate decarboxylase 1;glutamate decarboxylase 1 (brain, 67kDa);Glutamate decarboxylase 67 kDa isoform;SCP
- Extra Details:
- This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]
- Shipping Conditions:
- Blue Ice