GTX85444
NPAS3 antibody
Cannot supply to this region.
- SKU:
- GTX85444
- Additional Names:
- neuronal PAS domain protein 3 , MOP6 , PASD6 , bHLHe12
- Application:
- ELISA, WB, IHC-P
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- NPAS3 antibody was raised against a 28 amino acid synthetic peptide from near the center of human NPAS3.The immunogen is located within amino acids 470 - 520 of NPAS3.
- Uniprot:
- Q8IXF0
- Synonyms:
- basic-helix-loop-helix-PAS protein MOP6;bHLHe12;class E basic helix-loop-helix protein 12;member of PAS protein 6;MOP6;neuronal PAS domain-containing protein 3;neuronal PAS3;PAS domain-containing protein 6;PASD6
- Extra Details:
- Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor and is broadly expressed in the developing neuroepithelium and has recently found to be disrupted by genetic translocation in a family affected with schizophrenia. It was recently shown to be involved in the regulation of FGF signaling in the dentate gyrus by controlling the expression of the FGF receptor subtype 1 and in turn neurogenesis emanating from this region. NPAS3- mice were growth-retarded and displayed brain defects that included reduced size of the anterior hippocampus, hypoplasia of the corpus callosum, and enlargement of the ventricles, as well as several behavioral abnormalities. Furthermore, these NPAS3- mice also exhibited disruptions in several neurosignaling pathways involving glutamate, dopamine, and serotonin. These results demonstrate the essential role played by NPAS3 during structural and functional brain development. At least three isoforms of NPAS3 are known to exist.
- Shipping Conditions:
- Blue Ice