GTX85380
PRTFDC1 antibody
Cannot supply to this region.
- SKU:
- GTX85380
- Additional Names:
- phosphoribosyl transferase domain containing 1 , HHGP
- Application:
- ELISA, WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- PRTFDC1 antibody was raised against a 14 amino acid synthetic peptide from near the center of human PRTFDC1.The immunogen is located within amino acids 90 - 140 of PRTFDC1.
- Uniprot:
- Q9NRG1
- Synonyms:
- HHGP;phosphoribosyltransferase domain-containing protein 1
- Extra Details:
- Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.
- Shipping Conditions:
- Blue Ice