GTX85379
CNOT4 antibody
Cannot supply to this region.
- SKU:
- GTX85379
- Additional Names:
- CCR4-NOT transcription complex subunit 4 , CLONE243 , NOT4 , NOT4H
- Application:
- ELISA, WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- CNOT4 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of the human CNOT4.The immunogen is located within amino acids 70 - 120 of CNOT4.
- Uniprot:
- O95628
- Synonyms:
- CCR4-associated factor 4;CCR4-NOT transcription complex subunit 4;CLONE243;E3 ubiquitin-protein ligase CNOT4;NOT4;NOT4 (negative regulator of transcription 4, yeast) homolog;NOT4H;potential transcriptional repressor NOT4Hp;RING-type E3 ubiquitin transferase CNOT4
- Extra Details:
- CNOT4 is a component of the CCR4-NOT transcription complex, a complex that is implicated in the repression of RNA polymerase II transcription. In the CCR4-NOT complex, CNOT4 acts as an E3 ubiquitin-protein ligase and interacts with a subset of E2 ubiquitin-conjugating enzymes through a unique C4C4 RING domain. This E3 ligase activity was shown to be dependent on the selective and specific interaction with the ubiquitin conjugating enzyme UbcH5B. In yeast, mutations in CNOT4 that prevented its interaction with the UbcH5B homolog UBC4 caused increased sensitivity to hydroxyurea, heat shock, and hygromycin B, suggesting that CNOT4 and UbcH5B are involved in stress response in vivo. Multiple isoforms of CNOT4 are known to exist.
- Shipping Conditions:
- Blue Ice