GTX85281
MACC1 antibody
Cannot supply to this region.
- SKU:
- GTX85281
- Additional Names:
- MET transcriptional regulator MACC1 , 7A5 , SH3BP4L
- Application:
- ELISA, WB, IHC-P
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- MACC1 antibody was raised against a 17 amino acid synthetic peptide near the center of human MACC1.The immunogen is located within amino acids 430 - 480 of MACC1.
- Uniprot:
- Q6ZN28
- Synonyms:
- 7A5;MACC1, MET transcriptional regulator;metastasis associated in colon cancer 1;metastasis-associated in colon cancer protein 1;putative binding protein 7a5;SH3 domain-containing protein 7a5;SH3BP4L
- Extra Details:
- Metastasis associated in colon cancer 1 (MACC1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment. At least two isoforms of MACC1 are known to exist.
- Shipping Conditions:
- Blue Ice