PNAS4 antibody

Cannot supply to this region.

SKU:: GTX85277
Additional Names:: desumoylating isopeptidase 2 , C1orf121 , CGI-146 , DESI , DESI1 , DeSI-2 , FAM152A , PNAS-4 , PPPDE1
Application:: ELISA, WB
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: PBS, 0.02% Sodium azide.
Immunogen:: PNAS4 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human PNAS4.The immunogen is located within the last 50 amino acids of PNAS4.
Uniprot:: Q9BSY9
Synonyms:: C1orf121;CGI-146;DESI;DeSI-2;DESI1;desumoylating isopeptidase 1;Desumoylating isopeptidase 2;deubiquitinase DESI2;FAM152A;family with sequence similarity 152, member A;PNAS-4;PPPDE peptidase domain-containing protein 1;PPPDE1;Protein FAM152A
Extra Details:: PNAS4 is a highly conserved protein that shares high homology from plants to animals. It was initially identified as a putative apoptosis-related protein in the human acute promyelocytic leukemia cell line NB4. PNAS4 is activated during the early response to DNA damage and can inhibit proliferation via apoptosis when overexpressed in some tumor cells such as U2OS, SKOV3, and A549. PNAS4 inhibits tumor cell proliferation through the following mechanisms: (i) overexpression of PNAS4 causes S phase arrest by regulating the expression of cell cycle-related proteins and (ii) PNAS4 induces apoptosis through the mitochondrial apoptosis pathway. Recent evidence has shown that PNAS4 may be involved in the genesis of some cancers and could be a potential candidate for lung cancer therapy alone or in combination with gemcitabine. At least two isoforms of PNAS4 are known to exist.

Shipping Conditions:: Blue Ice