GTX85267
Ubiquilin 4 antibody
Cannot supply to this region.
- SKU:
- GTX85267
- Additional Names:
- ubiquilin 4 , A1U , A1Up , C1orf6 , CIP75 , UBIN
- Application:
- ELISA, WB, IHC-P
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- CIP75 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CIP75.The immunogen is located within the first 50 amino acids of CIP75.
- Uniprot:
- Q9NRR5
- Synonyms:
- A1U;A1Up;ataxin-1 interacting ubiquitin-like protein;ataxin-1 ubiquitin-like interacting protein;ataxin-1 ubiquitin-like-interacting protein A1U;C1orf6;CIP75;connexin43-interacting protein of 75 kDa;UBIN;ubiquilin-4
- Extra Details:
- The ubiquitin-proteosome pathway of protein degradation is one of the mechanisms that ensure the proper level of cellular proteins. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain containing protein family is thought to be involved in proteosomal degradation. One such protein is CIP75, also known as ubiquilin-4, interacts with a number of proteins such as Ataxin-1 and Connexin-43, resulting in an increased rate of turnover of these proteins. Overexpression CIP75 led to a significant reduction of Connexin-43 half-life, with the opposite being observed in siRNA knockdown experiments. CIP75 contains an N-terminal UbL domain which is thought to interact with proteins of the 26S proteosome complex and a C-terminal UBA domain which appears to mediate its interaction with Connexin-75. At least three isoforms of CIP75 are known to exist.
- Shipping Conditions:
- Blue Ice