GTX85263
PALB2 antibody
Cannot supply to this region.
- SKU:
- GTX85263
- Additional Names:
- partner and localizer of BRCA2 , FANCN , PNCA3
- Application:
- ELISA, WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- ABP:
- No Import Docs
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- PALB2 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human PALB2.The immunogen is located within amino acids 940 - 990 of PALB2.
- Uniprot:
- Q86YC2
- Synonyms:
- FANCN;mutant partner and localizer of BRCA2;partner and localizer of BRCA2;PNCA3;truncated partner and localizer of BRCA2
- Extra Details:
- The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments. At least four isoforms of PALB2 are known to exist.
- Shipping Conditions:
- Blue Ice