GTX85260
NOTUM antibody
Cannot supply to this region.
- SKU:
- GTX85260
- Additional Names:
- notum, palmitoleoyl-protein carboxylesterase , hNOTUM
- Application:
- ELISA, WB, IHC-P
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- NOTUM antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human NOTUM.The immunogen is located within amino acids 90 - 140 of NOTUM.
- Uniprot:
- Q6P988
- Synonyms:
- [Wnt protein] O-palmitoleoyl-L-serine hydrolase;hNOTUM;notum pectinacetylesterase homolog;palmitoleoyl-protein carboxylesterase NOTUM;protein notum homolog
- Extra Details:
- In Drosophila, the notum gene is regulated by the Wingless pathway and encodes a secreted hydrolase that modifies heparan sulfate proteoglycans. The mammalian homolog has been shown to be able to cleave glypicans and can release GPI-anchored proteins from the mammalian cell surface. Like the Drosophilia NOTUM, the mammalian protein can act as a negative regulator of the Wnt signaling pathway. NOTUM is expressed at a low level in most mammalian tissues, although it is overexpressed in a subset of human hepatocellular carcinomas. Its transcription is regulated by b-catenin/TCF and is a target of the Wnt signaling pathway, forming a negative feedback loop that regulates the expression and activity of the Wnt pathway.
- Shipping Conditions:
- Blue Ice