GTX85180
ZEB2 antibody
Cannot supply to this region.
- SKU:
- GTX85180
- Additional Names:
- zinc finger E-box binding homeobox 2 , HSPC082 , SIP-1 , SIP1 , SMADIP1 , ZFHX1B
- Application:
- ELISA, WB, IF, ICC
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- ZEB2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human ZEB2.The immunogen is located within the last 50 amino acids of ZEB2.
- Uniprot:
- O60315
- Synonyms:
- HSPC082;SIP-1;SIP1;SMAD interacting protein 1;Smad-interacting protein 1;SMADIP1;ZFHX1B;zinc finger E-box-binding homeobox 2;zinc finger homeobox 1b;Zinc finger homeobox protein 1b
- Extra Details:
- ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues (3). Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.
- Shipping Conditions:
- Blue Ice