GTX85177
TCTN2 antibody
Cannot supply to this region.
- SKU:
- GTX85177
- Additional Names:
- tectonic family member 2 , C12orf38 , JBTS24 , MKS8 , TECT2
- Application:
- ELISA, WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- TCTN2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TCTN2.The immunogen is located within amino acids 610 - 660 of TCTN2.
- Uniprot:
- Q96GX1
- Synonyms:
- C12orf38;JBTS24;MKS8;TECT2;tectonic-2
- Extra Details:
- TCTN2 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN2 is not known, it is 49% similar to TCTN1. TCTN1 is expressed during embryonic development in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
- Shipping Conditions:
- Blue Ice