NLRP7 antibody

Cannot supply to this region.

SKU:: GTX85156
Additional Names:: NLR family pyrin domain containing 7 , CLR19.4 , HYDM , NALP7 , NOD12 , PAN7 , PYPAF3
Application:: ELISA, WB, IHC-P
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human
Buffer:: PBS, 0.02% Sodium azide.
Immunogen:: NALP7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human NALP7.The immunogen is located within amino acids 90 - 140 of NALP7.
Uniprot:: Q8WX94
Synonyms:: CLR19.4;HYDM;NACHT, leucine rich repeat and PYD containing 7;NACHT, LRR and PYD containing protein 7;NACHT, LRR and PYD domains-containing protein 7;NALP7;NOD12;nucleotide-binding oligomerization domain protein 12;nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 7;PAN7;PYPAF3;PYRIN-containing Apaf1-like protein 3
Extra Details:: NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1beta secretion and is a feedback regulator of interleukin-1beta secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.

Shipping Conditions:: Blue Ice