GTX85082
UEV1A antibody
Cannot supply to this region.
- SKU:
- GTX85082
- Additional Names:
- ubiquitin conjugating enzyme E2 V1 , CIR1 , CROC-1 , CROC1 , UBE2V , UEV-1 , UEV1 , UEV1A
- Application:
- ELISA, WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Ion Exchange
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- UEV1A antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human UEV1A.The immunogen is located within the last 50 amino acids of UEV1A.
- Uniprot:
- Q13404
- Synonyms:
- CIR1;CROC-1;CROC-1B;CROC1;CROC1B;DNA-binding protein;KUA-UEV;TMEM189-UBE2V1;TMEM189-UBE2V1 fusion protein;TMEM189-UBE2V1 readthrough transcript;TRAF6-regulated IKK activator 1 beta Uev1A;transmembrane protein 189-ubiquitin-conjugating enzyme E2 variant 1 read-through;UBE2V;ubiquitin-conjugating enzyme E2 variant 1;UEV-1;UEV1;UEV1A
- Extra Details:
- Ubiquitin-conjugating enzyme E2 (UEV1) was initially discovered as a protein similar in sequence and structure to the E2 ubiquitin-conjugating enzymes but lacking their enzymatic activity (1). There are at least two variants and multiple isoforms of UEV1. In particular, UEV1A (Ubiquitin-conjugating enzyme E2 variant 1 isoform A) has recently been shown to be an important component of the Toll-like receptor and IL-1R signaling pathway (reviewed in 2). Signals from these pathways are relayed by a number of downstream molecules such as MyD88 and tumor necrosis factor receptor associated factor (TRAF6), ultimately activating various kinases and transcription factors (2,3). UEV1A is part of a dimeric ubiquitin-conjugating enzyme complex also containing Ubc13 (ubiquitin-conjugating enzyme 13) that together with TRAF6 activates TAK1, a member of the mitogen-activated protein kinase kinase kinase family (4-6). The Ubc13-UEV1A complex also mediates the Lys-63 ubiquitination of TRAF-6, and this ubiquitination is essential for TAK1 activation (5).
- Shipping Conditions:
- Blue Ice