GTX85052
CRLF2 antibody
Cannot supply to this region.
- SKU:
- GTX85052
- Additional Names:
- cytokine receptor like factor 2 , CRL2 , CRLF2Y , TSLPR
- Application:
- ELISA, WB, IHC-P
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- CRLF2 antibody was raised against a 19 amino acid synthetic peptide from near the center of human CRLF2.The immunogen is located within amino acids 140 - 190 of CRLF2.
- Uniprot:
- Q9HC73
- Synonyms:
- CRL2;CRLF2Y;cytokine receptor CRL2 precusor;Cytokine receptor-like 2;cytokine receptor-like factor 2;IL-XR;thymic stromal lymphopoietin protein receptor;thymic stromal-derived lymphopoietin receptor;TSLP receptor;TSLPR
- Extra Details:
- Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1. Despite its predicted molecular weight, TSLP-R often migrates at a higher molecular weight in SDS-PAGE.
- Shipping Conditions:
- Blue Ice