GTX85051
HUWE1 antibody
Cannot supply to this region.
- SKU:
- GTX85051
- Additional Names:
- HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 , ARF-BP1 , HECTH9 , HSPC272 , Ib772 , LASU1 , MULE , URE-B1 , UREB1
- Application:
- ELISA, WB, IF, ICC
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- HUWE1 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human HUWE1.The immunogen is located within amino acids 4250 - 4300 of HUWE1.
- Uniprot:
- Q7Z6Z7
- Synonyms:
- ARF-binding protein 1;ARF-BP1;BJ-HCC-24 tumor antigen;E3 ubiquitin-protein ligase HUWE1;HECT domain protein LASU1;HECT-type E3 ubiquitin transferase HUWE1;HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase;HECT, UBA and WWE domain-containing protein 1;HECTH9;homologous to E6AP carboxyl terminus homologous protein 9;HSPC272;Ib772;large structure of UREB1;LASU1;Mcl-1 ubiquitin ligase E3;MRXST;MULE;upstream regulatory element-binding protein 1;URE-B1;URE-binding protein 1;UREB1
- Extra Details:
- The ARF tumor suppressor is a critical regulator of p53 stability. In addition to p53, ARF1 binds to other proteins such as MDM2 and ARF-BP1, a large protein containing HECT, UBA and WWE motifs. ARF-BP1 directly binds and ubiquitinates p53; this activity is inhibited by ARF, indicating that ARF-BP1 is a critical mediator of the p53-dependent and p53-independent tumor suppressor functions of ARF. ARF-BP1 can also catalyze the polyubiquitination of Mcl-1, an anti-apoptotic Bcl-2 family member involved in DNA damage-induced apoptosis. Elimination of ARF-BP1 expression by RNA interference stabilized Mcl-1 protein, resulting in an attenuation of apoptosis induced by DNA-damage agents.
- Shipping Conditions:
- Blue Ice