GTX85044
KA1 antibody
Cannot supply to this region.
- SKU:
- GTX85044
- Additional Names:
- glutamate ionotropic receptor kainate type subunit 4 , EAA1 , GRIK , GluK4 , KA1
- Application:
- ELISA, WB, IHC-P
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- KA1 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of the human KA1.The immunogen is located within amino acids 30 - 80 of KA1.
- Uniprot:
- Q16099
- Synonyms:
- EAA1;excitatory amino acid receptor 1;GluK4;GluK4-2;GluK4(alt_5'UTR);glutamate receptor ionotropic, kainate 4;Glutamate receptor KA-1;glutamate receptor KA1;glutamate receptor, ionotropic, kainate 4;GRIK;KA1;putative NMDtranscript(altAcc_e11)
- Extra Details:
- Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Five subunits can assemble to form kainate receptors (KARs): GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits. In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of Grik4 with both schizophrenia and bipolar disorder. Despite its predicted molecular weight, Grik4 often migrates at a lower molecular weight in SDS-PAGE.
- Shipping Conditions:
- Blue Ice