IRGM antibody

Cannot supply to this region.

SKU:: GTX85039
Additional Names:: immunity related GTPase M , IFI1 , IRGM1 , LRG-47 , LRG47
Application:: ELISA, WB, IHC-P
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: PBS, 0.02% Sodium azide.
Immunogen:: IRGM antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of the human IRGM.The immunogen is located within amino acids 30 - 80 of IRGM.
Uniprot:: A1A4Y4
Synonyms:: IFI1;immunity-related GTPase family M protein;Immunity-related GTPase family M protein 1;immunity-related GTPase family, M1;interferon-inducible protein 1;IRGM1;LPS-stimulated RAW 264.7 macrophage protein 47 homolog;LRG-47;LRG-47-like protein;LRG47
Extra Details:: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn's disease. In mouse, IRGM belongs to a family of gamma-interferon-induced GTP-binding proteins of approximately 48 kDa. Murine IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. Human IRGM is also involved in autophagy and plays a role in the control of intracellular pathogens and in the reduction of intracellular bacillary load.

Shipping Conditions:: Blue Ice