CAPS1 antibody

Cannot supply to this region.

SKU:: GTX85037
Additional Names:: calcium dependent secretion activator , CADPS1 , CAPS , CAPS1 , UNC-31
Application:: ELISA, WB, IHC-P
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: PBS, 0.02% Sodium azide.
Immunogen:: CAPS1 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of the human CAPS1.The immunogen is located within the last 50 amino acids of CAPS1.
Uniprot:: Q9ULU8
Synonyms:: Ca++-dependent secretion activator;Ca2+ dependent secretion activator;Ca2+-dependent activator protein for secretion;Ca2+-regulated cytoskeletal protein;CADPS1;calcium-dependent activator protein for secretion 1;calcium-dependent secretion activator 1;CAPS;CAPS-1;CAPS1;UNC-31
Extra Details:: CAPS1 and its related protein CAPS2 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca2+-regulated exocytosis of secretory vesicles; CAPS-deficienct neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. CAPS1 acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate and is thought to be a specific regulator of large dense-core vesicle fusion. Numerous isoforms of CAPS1 are known to exist; the lower molecular weight bands seen in the immunoblot image are likely to be these isoforms. This CAPS1 antibody is predicted to be specific to CAPS1 and not recognize CAPS2.

Shipping Conditions:: Blue Ice