GTX85035
RIM2 antibody
Cannot supply to this region.
- SKU:
- GTX85035
- Additional Names:
- regulating synaptic membrane exocytosis 2 , OBOE , RAB3IP3 , RIM2
- Application:
- ELISA, WB, IHC-P
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- Rim2 antibody was raised against a 17 amino acid synthetic peptide near the center of the human Rim2.The immunogen is located within amino acids 250 - 300 of Rim2.
- Uniprot:
- Q9UQ26
- Synonyms:
- CRSDS;non-small cell lung cancer RimL3a protein;non-small cell lung cancer RimL3c protein;nuclear protein;OBOE;rab-3-interacting molecule 2;rab-3-interacting protein 3;RAB3 interacting protein 3;rab3-interacting molecule 2;Rab3-interacting protein;RAB3IP3;regulating synaptic membrane exocytosis protein 2;RIM2
- Extra Details:
- Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim 2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner. Rim2 is known to exist in multiple isoforms; this antibody should recognize most of them. This antibody is predicted to have no cross-reactivity to other Rim proteins.
- Shipping Conditions:
- Blue Ice