GTX85027
URP2 antibody
Cannot supply to this region.
- SKU:
- GTX85027
- Additional Names:
- fermitin family member 3 , KIND3 , MIG-2 , MIG2B , UNC112C , URP2 , URP2SF
- Application:
- ELISA, WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- URP2 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of the human URP2.The immunogen is located within the last 50 amino acids of URP2.
- Uniprot:
- Q86UX7
- Synonyms:
- fermitin family homolog 3;fermitin family member 3;KIND3;kindlin 3;Kindlin-3;MIG-2;MIG2-like protein;MIG2B;UNC-112 related protein 2;unc-112-related protein 2;UNC112C;URP2;URP2SF
- Extra Details:
- The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.
- Shipping Conditions:
- Blue Ice