GTX85022
MARCH8 antibody
Cannot supply to this region.
- SKU:
- GTX85022
- Additional Names:
- membrane associated ring-CH-type finger 8 , CMIR , MARCH-VIII , MIR , RNF178 , c-MIR
- Application:
- ELISA, WB, IF, ICC
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- MARCH8 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human MARCH8.The immunogen is located within the last 50 amino acids of MARCH8.
- Uniprot:
- Q5T0T0
- Synonyms:
- c-MIR;c-mir, cellular modulator of immune recognition;Cellular modulator of immune recognition;cellular modulator of immune recognition (c-MIR);CMIR;E3 ubiquitin-protein ligase MARCH8;E3 ubiquitin-protein ligase MARCHF8;MARCH-VIII;MARCH8;membrane associated ring finger 8;membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase;membrane-associated RING finger protein 8;membrane-associated RING-CH protein VIII;MIR;RING finger protein 178;RING-type E3 ubiquitin transferase MARCH8;RING-type E3 ubiquitin transferase MARCHF8;RNF178
- Extra Details:
- MARCH8 (c-MIR) is a novel E3 ubiquitin ligase designated as the modulator of immune recognition (MIR) family, whose catalytic domain is a variant RING domain (RING-CH domain). MARCH8 was found as a functional and structural homolog of KSHV MIR1 and MIR2. MARCH8 targets B7-2 to lysosomal degradation and down-regulates the B7-2 surface expression through ubiquitination of its cytoplasmic tail. Furthermore, MARCH8 has been shown to down-regulate the expression of transferrin receptor and Fas, an important molecule for the induction of apoptosis. MARCH8 is the first example of an E3 ubiquitin ligase that is capable of inhibiting MHC II expression. Recent findings suggest that MARCH8 may regulate immune responses by promoting ubiquitination of MHC-II and CD86, leading to their subsequent endocytosis and lysosomal degradation.
- Shipping Conditions:
- Blue Ice