BUB1B antibody [5D9]

Cannot supply to this region.

SKU:: GTX84771
Additional Names:: BUB1 mitotic checkpoint serine/threonine kinase B , BUB1beta , BUBR1 , Bub1A , MAD3L , MVA1 , SSK1 , hBUBR1
Application:: IHC, WB, IHC-P, IF, ICC
Concentration:: 1.2 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human
Buffer:: PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Full-length protein expressed in 293T cell transfected with human BUB1B expression vector
Clone:: 5D9
Uniprot:: O60566
Synonyms:: Bub1A;BUB1B, mitotic checkpoint serine/threonine kinase;BUB1beta;BUBR1;budding uninhibited by benzimidazoles 1 homolog beta;hBUBR1;MAD3/BUB1-related protein kinase;MAD3L;mitotic checkpoint kinase MAD3L;mitotic checkpoint serine/threonine-protein kinase BUB1 beta;MVA1;Protein SSK1;SSK1
Extra Details:: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.

Shipping Conditions:: Blue Ice