LIN7B antibody [1C9]

Cannot supply to this region.

SKU:: GTX84216
Additional Names:: lin-7 homolog B, crumbs cell polarity complex component , LIN-7B , MALS-2 , MALS2 , VELI2
Application:: Flow Cytometry, WB, IHC-P, IF, ICC
Concentration:: 0.58 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human
Buffer:: PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Full length human recombinant protein of human LIN7B (NP_071448) produced in HEK293T cell.
Clone:: 1C9
Uniprot:: Q9HAP6
Synonyms:: hLin7B;hVeli2;LIN-7B;MALS-2;MALS2;mammalian lin-seven protein 2;protein lin-7 homolog B;veli-2;VELI2;vertebrate lin-7 homolog 2
Extra Details:: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface.

Shipping Conditions:: Blue Ice