MOB1B antibody [1H2]

Cannot supply to this region.

SKU:: GTX84105
Additional Names:: MOB kinase activator 1B , MATS2 , MOB4A , MOBKL1A
Application:: Flow Cytometry, WB, IHC-P
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human
Buffer:: PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Full length human recombinant protein of human MOBKL1A(NP_775739) produced in HEK293T cell.
Clone:: 1H2
Uniprot:: Q7L9L4
Synonyms:: MATS2;MOB kinase activator 1B;mob1 homolog 1A;MOB1 Mps One Binder homolog B;MOB1, Mps One Binder kinase activator-like 1A;mob1A;Mob1B;MOB4A;MOBKL1A;mps one binder kinase activator-like 1A
Extra Details:: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

Shipping Conditions:: Blue Ice