PTPRE antibody [4B2]

Cannot supply to this region.

SKU:: GTX83763
Additional Names:: protein tyrosine phosphatase receptor type E , HPTPE , PTPE , R-PTP-EPSILON
Application:: Flow Cytometry, WB, IHC-P, IF, ICC
Concentration:: 0.89 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human
Buffer:: PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Full length human recombinant protein of human PTPRE (NP_006495) produced in HEK293T cell.
Clone:: 4B2
Uniprot:: P23469
Synonyms:: HPTPE;protein tyrosine phosphatase, receptor type, epsilon polypeptide;PTPE;R-PTP-EPSILON;receptor-type tyrosine-protein phosphatase epsilon
Extra Details:: Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function. Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake. Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).

Shipping Conditions:: Blue Ice