RIC8A antibody [3G3]

Cannot supply to this region.

SKU:: GTX83714
Additional Names:: RIC8 guanine nucleotide exchange factor A , RIC8
Application:: WB, IHC-P, IF, ICC
Concentration:: 0.83 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human
Buffer:: PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Full length human recombinant protein of human RIC8A (NP_068751) produced in HEK293T cell.
Clone:: 3G3
Uniprot:: Q9NPQ8
Synonyms:: Protein Ric-8A;resistance to inhibitors of cholinesterase 8 homolog A;RIC8;synembryn-A
Extra Details:: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.