![SATB1 antibody [6C6]](https://www.genetex.com/upload/website/prouct_img/normal/GTX83685/GTX83685_3818_WB_w_23061420_452.webp)
![SATB1 antibody [6C6]](https://www.genetex.com/upload/website/prouct_img/normal/GTX83685/GTX83685_3819_WB_w_23061420_785.webp)
![SATB1 antibody [6C6]](https://www.genetex.com/upload/website/prouct_img/normal/GTX83685/GTX83685_772_ICCIF_w_23061420_918.webp)
GTX83685
SATB1 antibody [6C6]
Cannot supply to this region.
- SKU:
- GTX83685
- Additional Names:
- SATB homeobox 1
- Application:
- WB, IF, ICC
- Concentration:
- 0.75 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Mouse
- Reactivities:
- Human
- Buffer:
- PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- Full-length protein expressed in 293T cell transfected with human SATB1 expression vector
- Clone:
- 6C6
- Uniprot:
- Q01826
- Synonyms:
- DEFDA;DNA-binding protein SATB1;KTZSL;special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA);Special AT-rich sequence-binding protein 1
- Extra Details:
- Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly upregulating metastasis-associated genes while downregulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.
- Shipping Conditions:
- Blue Ice