SHC1 antibody [1D3]

Cannot supply to this region.

SKU:: GTX83655
Additional Names:: SHC adaptor protein 1 , SHC , SHCA
Application:: Flow Cytometry, WB, IF, ICC
Concentration:: 0.93 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human
Buffer:: PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Full length human recombinant protein of human SHC1 (NP_003020) produced in HEK293T cell.
Clone:: 1D3
Uniprot:: P29353
Synonyms:: SH2 domain protein C1;SHC;SHC (Src homology 2 domain containing) transforming protein 1;SHC-transforming protein 1;SHC-transforming protein 3;SHC-transforming protein A;SHCA;Src homology 2 domain-containing-transforming protein C1
Extra Details:: Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span.

Shipping Conditions:: Blue Ice