STK3 antibody [4G10]

Cannot supply to this region.

SKU:: GTX83546
Additional Names:: serine/threonine kinase 3 , KRS1 , MST2
Application:: WB, IHC-P
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Canine, Human, Mouse
Buffer:: PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Full-length protein expressed in 293T cell transfected with human STK3 expression vector
Clone:: 4G10
Uniprot:: Q13188
Synonyms:: epididymis secretory sperm binding protein;hippo homolog;KB-1458E12.1;KRS1;mammalian STE20-like protein kinase 2;MST-2;MST2;serine/threonine kinase 3 (STE20 homolog, yeast);serine/threonine kinase 3 (Ste20, yeast homolog);serine/threonine-protein kinase 3;serine/threonine-protein kinase Krs-1;STE20-like kinase MST2
Extra Details:: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1.

Shipping Conditions:: Blue Ice