TIF1 gamma antibody [9D4]

Cannot supply to this region.

SKU:: GTX83492
Additional Names:: tripartite motif containing 33 , ECTO , PTC7 , RFG7 , TF1G , TIF1G , TIF1GAMMA , TIFGAMMA
Application:: WB, IHC-P, IF, ICC
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human
Buffer:: PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Human recombinant protein fragment corresponding to amino acids 887-1046 of human Trim33 (NP_056990) produced in E.coli.
Clone:: 9D4
Uniprot:: Q9UPN9
Synonyms:: E3 ubiquitin-protein ligase TRIM33;ECTO;ectodermin homolog;protein Rfg7;PTC7;RET-fused gene 7 protein;RFG7;RING-type E3 ubiquitin transferase TRIM33;TF1G;TIF1-gamma;TIF1G;TIF1GAMMA;TIFGAMMA;Transcription intermediary factor 1-gamma;transcriptional intermediary factor 1 gamma;Tripartite motif-containing protein 33
Extra Details:: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).

Shipping Conditions:: Blue Ice